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Buy Columvi (Glofitamab) Medicine in India

Columvi (Glofitamab)

Medicine name : Columvi

Generic name : Glofitamab

Manufactured By : Roche

Indications : Diffuse Large B-Cell Lymphoma or LBCL

Medicine Description : Columvi is a bispecific antibody therapy for relapsed or refractory diffuse large B-cell lymphoma (DLBCL). It binds to CD20 on cancer cells and CD3 on T-cells, activating an immune response. Given via IV infusion, it enhances T-cell-mediated tumor destruction. Side effects include cytokine release syndrome (CRS), fever, and low blood counts. Careful monitoring helps manage severe immune reactions.

Product Introduction

Columvi (Glofitamab) is a targeted immunotherapy used to treat certain types of relapsed or refractory diffuse large B-cell lymphoma (DLBCL) in adults. It is a bispecific antibody that helps the immune system recognize and destroy abnormal B-cells, making it an important treatment option for eligible patients whose cancer has returned or stopped responding to previous therapies.

Columvi (Glofitamab) is administered by a healthcare professional through an intravenous infusion according to a specific treatment schedule. The dose is gradually increased at the beginning of treatment to reduce the risk of serious reactions. Your doctor will determine the appropriate treatment schedule based on your condition and response to therapy. Close medical monitoring is required during treatment.

Common side effects of Columvi (Glofitamab) may include cytokine release syndrome (CRS), fever, fatigue, muscle and joint pain, rash, nausea, diarrhea, and low blood cell counts. Serious immune-related reactions and nervous system problems can also occur. Inform your doctor about your medical history and all medicines or supplements you are taking. Seek immediate medical attention if you develop high fever, chills, difficulty breathing, confusion, severe dizziness, or other unusual symptoms during or after treatment.

Uses Of Columvi (Glofitamab)

Treatment of Diffuse Large B-Cell Lymphoma (DLBCL)

Benefits Of Columvi

Columvi (Glofitamab) is used to treat adults with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) after previous treatments have stopped working or the cancer has returned. It helps the immune system identify and attack abnormal B-cells by bringing T-cells into close contact with lymphoma cells. This can reduce cancer cell growth and help control the progression of the disease.

Side Effects Of Columvi (Glofitamab)

Some side effects of Columvi (Glofitamab) may improve as your body adjusts to the treatment. Consult your doctor if any side effect persists, becomes severe, or causes concern.

Common Side Effects of Columvi (Glofitamab)

  • Cytokine release syndrome (CRS)
  • Fever
  • Fatigue
  • Muscle pain
  • Joint pain
  • Rash
  • Nausea
  • Diarrhea
  • Low red blood cell count
  • Low white blood cell count
How To Use Columvi

Columvi (Glofitamab) is administered by a healthcare professional through an intravenous infusion. Treatment begins with gradually increasing doses before the recommended treatment dose is given, helping reduce the risk of cytokine release syndrome. Your doctor will determine the treatment schedule based on your condition and response to therapy. Close medical monitoring is required, particularly during the initial doses.

How Columvi (Glofitamab) Works

Columvi (Glofitamab) is a bispecific antibody that connects T-cells with CD20-positive B-cells, including abnormal lymphoma cells. By bringing T-cells close to the cancer cells, it activates the immune system to attack and destroy them. This helps reduce lymphoma cells and may slow the progression of diffuse large B-cell lymphoma (DLBCL).

Storage Conditions
  • Keep the unopened vial refrigerated between 2°C and 8°C.
  • Retain the vial in its original carton to protect it from light.
  • Do not freeze or shake the vial during storage.
  • After dilution, the solution can be refrigerated at 2°C to 8°C for up to 64 hours or kept at room temperature up to 25°C for 4 hours.
Safety Advice

AlcoholAlcohol CONSULT YOUR DOCTOR

Consult your doctor before consuming alcohol during treatment with Columvi (Glofitamab).

PregnancyPregnancy CONSULT YOUR DOCTOR

Columvi (Glofitamab) may harm an unborn baby. Inform your doctor if you are pregnant or planning to become pregnant.

BreastfeedingBreastfeeding CONSULT YOUR DOCTOR

Consult your doctor before breastfeeding during treatment with Columvi (Glofitamab), as the potential risk to the infant is not fully known.

DrivingDriving CONSULT YOUR DOCTOR

Columvi (Glofitamab) may cause dizziness, fatigue, or nervous system effects. Avoid driving if these symptoms affect your alertness or coordination.

KidneyKidney CAUTION

Inform your doctor if you have kidney problems before starting treatment with Columvi (Glofitamab). Your doctor will determine the appropriate treatment and monitoring.

LiverLiver CAUTION

Tell your doctor if you have liver problems. Liver function may be monitored during treatment with Columvi (Glofitamab).

Quick Tips
  • Attend all scheduled appointments and follow your doctor's treatment schedule, especially during the initial doses of Columvi (Glofitamab).
  • Report fever, chills, low blood pressure, rapid heartbeat, breathing difficulties, or other symptoms that may indicate cytokine release syndrome (CRS).
  • Contact your doctor immediately if you experience confusion, severe dizziness, difficulty speaking, loss of coordination, or other nervous system changes.
  • Inform your doctor about all medicines, vitamins, herbal products, and dietary supplements you are taking to help prevent possible interactions.
  • Do not change, interrupt, or stop Columvi (Glofitamab) treatment without your doctor's advice.
  • Read More About - Columvi (Glofitamab) from Pharma Five.
About Pharma Five

Pharma Five, can support patients in arranging the import of Columvi (Glofitamab) in small quantities for personal use. For this purpose, the applicant is required to submit an application in Form 12A, accompanied by a prescription issued by a Registered Medical Practitioner (RMP).

Through its pharmaceutical consultancy and facilitation services, Pharma Five helps patients obtain access to Columvi (Glofitamab) and other specialized medicines through professional import assistance. Pharma Five provides extensive pharmaceutical service coverage across India, serving patients and healthcare requirements in prominent cities such as Mumbai, Delhi, Kolkata, Bhubaneswar, Bangalore, Hyderabad, Chennai, Ahmedbad, Pune, Surat, Visakhapatnam, Jaipur, Lucknow, Nagpur, Indore, Patna, Agartala, Guwahati, Imphal, Kohima, Namchi, Noida, Ghaziabad, Ludhiana, Agra, Varanasi, Srinagar, Amritsar, Jodhpur, Chandigarh, Gurgaon, Gorakhpur, Dehradun, Jammu, Hyderabad, Thiruvananthapuram, Kochi, Coimbatore, Puducherry, Mysuru, Salem, Vellore, Tiruppur, Guntur, Goa, Kolhapur, Mumbai, Nashik, and various other regions in India.

References
  1. https://go.drugbank.com/drugs/DB16371
  2. https://www.ncbi.nlm.nih.gov/books/NBK619912/
  3. https://www.fda.gov/drugs/drug-approvals-and-databases/fda-grants-accelerated-approval-glofitamab-gxbm-selected-relapsed-or-refractory-large-b-cell
  4. https://www.cancer.gov/about-cancer/treatment/drugs/glofitamab-gxbm
  5. https://www.tga.gov.au/resources/auspmd/columvi
  6. https://www.ema.europa.eu/en/medicines/human/EPAR/columvi
Faq

General Question

Columvi (Glofitamab) is a prescription drug used to treat certain types of non-Hodgkin’s lymphoma, particularly diffuse large B-cell lymphoma (DLBCL) in adults who have tried at least two previous treatments.

Columvi is a bispecific antibody that binds to both cancerous B-cells and immune system T-cells, helping the body’s immune system attack and destroy lymphoma cells.

Columvi is prescribed for adults with relapsed or refractory DLBCL after prior therapies have failed. A doctor will assess if it is the right treatment based on the patients condition.

Columvi is given as an intravenous (IV) infusion in a hospital or clinic setting. The dosing schedule is determined by the doctor and typically involves step-up dosing to manage side effects.

Common side effects include fever, fatigue, nausea, headache, diarrhea, low white blood cell count (neutropenia), and infusion-related reactions.

Yes, Columvi may cause serious side effects such as cytokine release syndrome (CRS), severe infections, low blood cell counts, and heart issues. Immediate medical attention is needed for severe reactions.

Treatment duration depends on the doctor’s recommendation and how well the patient responds. Columvi is usually given for a fixed number of cycles rather than long-term use.

It is best to avoid alcohol as it may worsen side effects like fatigue and liver-related complications. Consult your doctor before consuming alcohol.

No, Columvi may harm an unborn baby. Women should use effective contraception while on treatment and for some time after the last dose.

Yes, Columvi may interact with other drugs, including immunosuppressants, blood thinners, and chemotherapy agents. Inform your doctor about all the medicines you take.

If you miss an appointment for an infusion, contact your healthcare provider immediately to reschedule.

Since Columvi is given as an IV infusion, food does not directly affect it. However, maintaining proper nutrition can support overall treatment tolerance.

Monitor for infusion reactions like fever, chills, or difficulty breathing. Avoid infections by practicing good hygiene and avoiding sick individuals

Columvi is stored in a hospital or pharmacy under controlled refrigerated conditions and should only be handled by healthcare professionals.

Columvi is available by prescription and is administered in hospitals or specialty infusion centers. Consult your doctor for access and availability. Pharma Five assists in its procurement.

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