Pharma Five is a registered firm based in India. We specialize in Named Patient Imports, Imported cancer drugs, Imported medicines in india.
Contact Us Pharma Five Door No. 74, Old No. 26, Fagun Mansion, 3rd Floor, Ethiraj Salai, Egmore, Chennai - 600008 +916374297988 info@pharmafive.org
Medicine name : Koselugo
Generic name : Selumetinib
Manufactured By : Astra Zeneca
Indications : Neuro Fibromatosis Type 1
Medicine Description : A MEK inhibitor approved for pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas. It targets abnormal cell growth signaling pathways, reducing tumor size and improving symptoms.
Koselugo (Selumetinib) is a prescription medicine used to treat children aged 2 years and older with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas (tumors growing along nerves).
Koselugo is a MEK inhibitor that blocks specific enzymes (MEK1 and MEK2) involved in cell growth. By targeting these enzymes, it helps shrink or slow the growth of NF1-related tumors.
Koselugo is approved for pediatric patients 2 years and older with NF1 and symptomatic, inoperable plexiform neurofibromas. It must be prescribed and monitored by a healthcare professional experienced in NF1 treatment.
Koselugo is taken orally as a capsule, usually twice daily (every 12 hours) on an empty stomach—1 hour before or 2 hours after eating. The dosage is based on the patient’s body surface area.
Common side effects include diarrhea, nausea, vomiting, abdominal pain, fatigue, skin rash, dry skin, and mouth sores.
Yes, serious side effects can include heart problems, eye problems (including vision changes), liver damage, and muscle pain or weakness. Regular monitoring is required.
Koselugo is taken as long as it remains effective and is tolerated well. The treating physician will regularly assess the patient’s response and side effects to determine treatment duration.
It is best to avoid alcohol during treatment, as it may increase the risk of liver problems and worsen side effects like fatigue or nausea.
No, Koselugo may harm an unborn baby. Female patients should use effective contraception during treatment and for a period after the last dose. Breastfeeding is also not recommended.
Yes, Koselugo can interact with other medications, including certain antifungals, antibiotics, and seizure medications. Always inform your doctor about all medicines and supplements being used.
If a dose is missed, take it as soon as remembered if its within 6 hours of the scheduled time. If more than 6 hours have passed, skip the missed dose and take the next dose at the regular time. Do not double up.
No, Koselugo should be taken on an empty stomach—at least 1 hour before or 2 hours after food—for best absorption and effectiveness.
Get regular heart, eye, and liver function checks; report any unusual symptoms immediately; avoid sun exposure and use sunscreen to protect the skin.
Store Koselugo capsules at room temperature in a dry place, away from light and moisture. Keep out of reach of children.
Koselugo is available by prescription and typically dispensed through specialty pharmacies. Your doctor can guide you on how to access it through approved channels. Pharma Five assists in its procurement.