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Medicine name : Istodax
Generic name : Romidepsin
Manufactured By : Celgene
Indications : Cutaneous T-Cell Lymphoma (CTCL)
Medicine Description : Istodax is an HDAC inhibitor for relapsed/refractory peripheral T-cell lymphoma (PTCL). It alters gene expression, leading to cancer cell death. Given via IV infusion, it extends survival in aggressive lymphomas. Side effects include low blood counts, infections, nausea, and heart rhythm disturbances. ECG and blood count monitoring are required to manage risks.
Istodax (Romidepsin) is a prescription cancer medicine used to treat cutaneous T-cell lymphoma (CTCL) and peripheral T-cell lymphoma (PTCL) in adults who have received at least one prior treatment.
Istodax is a histone deacetylase (HDAC) inhibitor. It works by altering the expression of genes in cancer cells, stopping their growth and triggering cell death.
Istodax is prescribed for adults with CTCL or PTCL who have not responded to or have relapsed after previous treatments.
Istodax is given as an intravenous (IV) infusion, usually over a 4-hour period on days 1, 8, and 15 of a 28-day treatment cycle. It is administered in a medical setting.
Common side effects include nausea, fatigue, vomiting, loss of appetite, low blood counts, and infections.
Yes, Istodax can cause serious side effects such as heart rhythm problems (QT prolongation), severe infections, and low platelet or white blood cell counts. Contact your doctor if you experience chest pain, dizziness, or unusual bruising.
Treatment duration varies based on your response and how well you tolerate it. Your doctor will determine how many cycles are appropriate for you.
It’s best to avoid alcohol during treatment, as it may increase the risk of liver problems and worsen side effects like nausea or fatigue.
No, Istodax may harm an unborn baby. Both men and women should use effective contraception during treatment and for some time after the last dose.
Yes, Istodax can interact with other drugs, especially those affecting liver enzymes or heart rhythm. Inform your doctor of all the medications and supplements you are taking.
If you miss a scheduled IV dose, contact your healthcare provider right away. They will reschedule your infusion appropriately.
Istodax is administered via IV, so food does not affect its administration. However, eating light meals before infusions may help reduce nausea.
Attend all scheduled blood tests and check-ups, avoid contact with sick people, report any signs of infection or bleeding, and stay hydrated during treatment.
Istodax is stored and handled by medical professionals in a healthcare facility. Patients do not need to store it at home.
Istodax is available at hospitals or oncology centers where it is administered by trained healthcare professionals. Your doctor will guide you on access and scheduling. Pharma Five assists in its procurement.