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Medicine name : Synribo
Generic name : Omacetaxine
Manufactured By : Cephalon
Indications : CML with more than 2 TKI failures
Medicine Description : Synribo is an oral chemotherapy for chronic myeloid leukemia (CML) in the chronic or accelerated phase after failure of other therapies. It inhibits protein synthesis, leading to cancer cell death. Given subcutaneously, it is effective in resistant cases. Side effects include low blood counts, injection site reactions, fatigue, and gastrointestinal symptoms. Blood tests are required to monitor for side effects.
Synribo (Omacetaxine mepesuccinate) is a prescription medicine used to treat adults with chronic or accelerated phase chronic myeloid leukemia (CML) who are no longer responding to or cannot tolerate two or more tyrosine kinase inhibitors (TKIs).
Synribo is a protein synthesis inhibitor. It works by preventing the cancer cells from making proteins they need to grow, leading to their death and slowing the progression of leukemia.
Synribo is intended for adults with chronic or accelerated phase CML who have failed treatment with at least two TKIs.
Synribo is administered by a healthcare provider as a subcutaneous (under the skin) injection, typically twice daily for 14 days of a 28-day cycle during the initial treatment phase.
Common side effects include low blood cell counts, diarrhea, nausea, fatigue, fever, and reactions at the injection site.
Yes, serious side effects can include severe bone marrow suppression, infections, bleeding, and low blood counts. Your doctor will monitor blood tests frequently during treatment.
Synribo treatment continues as long as it is effective and tolerable. Your doctor will assess your response and adjust your treatment plan accordingly.
It is best to avoid alcohol while taking Synribo, as it may increase the risk of liver problems and worsen side effects like fatigue or nausea.
No, Synribo can harm an unborn baby. Effective contraception should be used during treatment and for some time afterward.
Yes, Synribo may interact with other drugs. Tell your doctor about all medications, including over-the-counter medicines and supplements.
If you miss a dose, contact your healthcare provider for instructions. Do not take an extra dose without medical advice.
Synribo is given by injection and is not affected by food. However, staying well-nourished may help your body better tolerate treatment.
Avoid people who are sick, report signs of infection or bleeding, and attend all scheduled blood tests and appointments.
Synribo should be stored in the refrigerator by the healthcare facility. If you are administering it at home (under guidance), follow the storage instructions provided.
Synribo is available through specialty pharmacies or oncology centers with a valid prescription and treatment plan. Your doctor will coordinate its access and administration. Pharma Five assists in its procurement.