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Medicine name : Ziftomenib
Generic name : Komzifti
Manufactured By : Cura Onco
Indications : Relapsed/Refractory NPM1-Mutated AML
Medicine Description : A targeted oral therapy for relapsed or refractory NPM1-mutated acute myeloid leukemia (AML), Ziftomenib (Komzifti) is a menin inhibitor that disrupts the menin–KMT2A interaction, helping suppress leukemia cell growth driven by NPM1 mutations. It is used in patients whose disease has returned or not responded to prior treatments. Taken orally, it offers a precision-based treatment approach with the potential to improve clinical outcomes. Common side effects include nausea, fatigue, anemia, thrombocytopenia, and elevated liver enzymes. Regular monitoring is required to manage blood counts, liver function, and overall treatment safety.