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Buy Inrebic (Fedratinib) Medicine in India

Inrebic (Fedratinib)

Medicine name : Inrebic

Generic name : Fedratinib

Manufactured By : Celgene

Indications : Myelofibrosis

Medicine Description : Inrebic is a JAK2 inhibitor used for myelofibrosis, a bone marrow cancer. It reduces spleen size and alleviates symptoms like anemia and fatigue. Taken orally, it improves quality of life. Side effects include nausea, diarrhea, dizziness, and severe brain complications (Wernicke’s encephalopathy). Patients need thiamine level monitoring to prevent neurological risks.

Product Introduction

Inrebic (Fedratinib) is a targeted anticancer medicine used to treat adults with intermediate-2 or high-risk primary myelofibrosis (MF), post-polycythemia vera myelofibrosis, or post-essential thrombocythemia myelofibrosis. It belongs to a group of medicines called Janus kinase (JAK) inhibitors and works mainly by blocking abnormal JAK2 signaling involved in the growth of blood cells and development of myelofibrosis.

Inrebic (Fedratinib) should be taken exactly as prescribed by your doctor, usually once daily with or without food. Taking it with a meal may help reduce nausea. Swallow the capsule whole with water and do not crush, chew, or open it. Your doctor may prescribe thiamine (vitamin B1) before and during treatment and may recommend regular blood tests to monitor your blood counts, liver and kidney function, and thiamine levels.

Common side effects of Inrebic may include diarrhea, nausea, vomiting, fatigue, anemia, and low platelet counts. It can also cause serious thiamine deficiency and a condition called Wernicke's encephalopathy, which may cause confusion, difficulty walking, vision problems, or other neurological symptoms. Contact your doctor immediately if you develop these symptoms, severe vomiting or diarrhea, unusual weakness, or other concerning effects. Before starting treatment, inform your doctor about any medical conditions and all medicines, vitamins, herbal products, and supplements you are taking.

Uses Of Inrebic (Fedratinib)

Treatment of Myelofibrosis

Benefits Of Inrebic

Inrebic (Fedratinib) is used to treat adults with intermediate-2 or high-risk primary myelofibrosis, post-polycythemia vera myelofibrosis, or post-essential thrombocythemia myelofibrosis. It mainly blocks abnormal JAK2 signaling, which can help reduce an enlarged spleen and improve symptoms associated with myelofibrosis, such as abdominal discomfort, fatigue, bone or muscle pain, itching, and early fullness after eating. By controlling abnormal blood-cell signaling, Fedratinib helps manage the disease and may slow its progression.

Side Effects Of Inrebic (Fedratinib)

Some side effects of Inrebic (Fedratinib) may improve as your body adjusts to the medicine. Consult your doctor if any side effect persists, becomes severe, or causes concern.

Common Side Effects of Inrebic (Fedratinib)

  • Diarrhea
  • Nausea
  • Vomiting
  • Fatigue
  • Anemia
  • Low platelet count
  • Constipation
  • Headache
  • Muscle or bone pain
  • Increased liver enzymes
How To Use Inrebic

Inrebic (Fedratinib) should be taken exactly as prescribed by your doctor, usually once daily. It may be taken with or without food, although taking it with a meal may help reduce nausea and vomiting. Swallow the capsule whole with water and do not crush, chew, or open it. Your doctor may prescribe thiamine (vitamin B1) before and during treatment and may recommend regular blood tests to monitor your blood counts, liver and kidney function, and thiamine levels.

How Inrebic (Fedratinib) Works

Inrebic (Fedratinib) is a JAK2 inhibitor that blocks abnormal JAK2 signaling involved in the production and growth of blood cells. By reducing these abnormal signals, Fedratinib helps control the excessive blood-cell production associated with myelofibrosis. This can help reduce spleen enlargement and improve symptoms such as fatigue, abdominal discomfort, bone or muscle pain, itching, and early fullness after eating.

Storage Conditions
  • Keep Inrebic capsules at a temperature below 30°C.
  • Store the capsules in the original bottle with the container tightly closed.
  • Protect the medicine from moisture during storage.
  • Keep the bottle in a safe place that is out of the sight and reach of children.
Safety Advice

AlcoholAlcohol CONSULT YOUR DOCTOR

Consult your doctor before consuming alcohol during treatment with Inrebic (Fedratinib).

PregnancyPregnancy CONSULT YOUR DOCTOR

Inform your doctor if you are pregnant or planning to become pregnant. Fedratinib may potentially harm an unborn baby.

BreastfeedingBreastfeeding CONSULT YOUR DOCTOR

Consult your doctor before breastfeeding during treatment with Inrebic (Fedratinib).

DrivingDriving CONSULT YOUR DOCTOR

Inrebic may cause dizziness, fatigue, or weakness. Avoid driving if these symptoms affect your alertness or ability to drive safely.

KidneyKidney CAUTION

Inform your doctor if you have kidney problems before starting treatment. Your doctor may adjust the dose and monitor kidney function.

LiverLiver CAUTION

Tell your doctor if you have liver problems. Liver function may be monitored during treatment, and dose adjustment may be required.

Quick Tips
  • Take Inrebic (Fedratinib) exactly as prescribed by your doctor and follow the recommended treatment schedule.
  • Take thiamine (vitamin B1) supplements as prescribed and attend regular blood tests to monitor your thiamine levels and overall health.
  • Contact your doctor if you experience persistent or severe diarrhea, nausea, or vomiting, as these may lead to dehydration.
  • Seek immediate medical attention if you develop confusion, difficulty walking, vision problems, severe weakness, or other signs of thiamine deficiency.
  • Inform your doctor about all medicines, vitamins, herbal products, and dietary supplements you are taking to help prevent possible drug interactions.
  • Read More About - Inrebic (Fedratinib) from Pharma Five.
About Pharma Five

Pharma Five, can facilitate patients in importing Inrebic (Fedratinib) in small quantities for personal use. To complete the import process, the applicant must submit an application in Form 12A along with a prescription issued by a Registered Medical Practitioner (RMP).

Pharma Five assists patients seeking Inrebic (Fedratinib) by providing experienced pharmaceutical consultancy and facilitation services for accessing specialized medicines through the appropriate import process. Pharma Five provides extensive pharmaceutical service coverage across India, serving patients and healthcare requirements in prominent cities such as Mumbai, Delhi, Kolkata, Bhubaneswar, Bangalore, Hyderabad, Chennai, Ahmedbad, Pune, Surat, Visakhapatnam, Jaipur, Lucknow, Nagpur, Indore, Patna, Agartala, Guwahati, Imphal, Kohima, Namchi, Noida, Ghaziabad, Ludhiana, Agra, Varanasi, Srinagar, Amritsar, Jodhpur, Chandigarh, Gurgaon, Gorakhpur, Dehradun, Jammu, Hyderabad, Thiruvananthapuram, Kochi, Coimbatore, Puducherry, Mysuru, Salem, Vellore, Tiruppur, Guntur, Goa, Kolhapur, Mumbai, Nashik, and various other regions in India.

References
  1. https://go.drugbank.com/drugs/DB12500
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/212327s004lbl.pdf
  3. https://www.ema.europa.eu/en/medicines/human/EPAR/inrebic
Faq

General Question

Inrebic (Fedratinib) is a prescription medication used to treat myelofibrosis, a type of bone marrow cancer that disrupts normal blood cell production.

Inrebic is a Janus kinase 2 (JAK2) inhibitor that helps reduce symptoms of myelofibrosis by blocking the abnormal signals that cause bone marrow scarring and enlarged spleen.

Doctors prescribe Inrebic for adults with intermediate-2 or high-risk primary or secondary myelofibrosis.

Inrebic is taken orally as a capsule, usually once daily, with or without food.

Common side effects include nausea, diarrhea, vomiting, dizziness, fatigue, and low blood cell counts.

Yes, Inrebic may cause serious side effects such as severe anemia, neurological problems (including Wernicke’s encephalopathy), and liver toxicity. Seek medical help for severe symptoms.

Inrebic is taken as long as it remains effective and tolerable, or until a doctor advises stopping treatment.

It is best to avoid alcohol while taking Inrebic, as it may increase the risk of liver problems and worsen side effects.

No, Inrebic may harm an unborn baby. Women should use effective contraception while taking this medication.

Yes, Inrebic can interact with certain medications, including antifungals, antibiotics, and seizure drugs. Inform your doctor about all medications you take.

If you miss a dose, take it as soon as you remember, but skip it if your next dose is soon. Do not take two doses together.

Yes, Inrebic can be taken with or without food, but taking it with a meal may help reduce stomach discomfort.

Drink plenty of fluids to prevent dehydration, monitor blood counts regularly, and avoid grapefruit while taking Inrebic.

Store Inrebic at room temperature, away from moisture and heat, and keep it out of reach of children.

Inrebic is available by prescription at pharmacies or through specialty drug providers. Consult your doctor for the best source. Pharma Five assists in its procurement.

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